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Effect of implanted fillers on the recruitment of PSCs and ingrowth of blood vessels following implantation in the periosteum of rat skull for a duration of 1 month. Scale bars, 100 μm. A Representative immunostainings of <t>LepR+</t> PSCs, Emcn+ vessels, and OPN+ mature osteoblast in HA and PCL fillers. B , C Quantification of the relative Emcn+ vessel area in implants ( B ) and peri-implants ( C ). D Quantification of the relative LepR+ area in implants. Data are means ± SD. * P < 0.05, and *** P < 0.005 (unpaired two-tailed Student’s t test)
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Effect of implanted fillers on the recruitment of PSCs and ingrowth of blood vessels following implantation in the periosteum of rat skull for a duration of 1 month. Scale bars, 100 μm. A Representative immunostainings of <t>LepR+</t> PSCs, Emcn+ vessels, and OPN+ mature osteoblast in HA and PCL fillers. B , C Quantification of the relative Emcn+ vessel area in implants ( B ) and peri-implants ( C ). D Quantification of the relative LepR+ area in implants. Data are means ± SD. * P < 0.05, and *** P < 0.005 (unpaired two-tailed Student’s t test)
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Effect of implanted fillers on the recruitment of PSCs and ingrowth of blood vessels following implantation in the periosteum of rat skull for a duration of 1 month. Scale bars, 100 μm. A Representative immunostainings of LepR+ PSCs, Emcn+ vessels, and OPN+ mature osteoblast in HA and PCL fillers. B , C Quantification of the relative Emcn+ vessel area in implants ( B ) and peri-implants ( C ). D Quantification of the relative LepR+ area in implants. Data are means ± SD. * P < 0.05, and *** P < 0.005 (unpaired two-tailed Student’s t test)

Journal: Aesthetic Plastic Surgery

Article Title: A Rat Model Investigation of Enhanced Facial Rejuvenation via PCL Microsphere-Induced Superior Collagen Neogenesis in the Supraperiosteal Plane

doi: 10.1007/s00266-025-05503-6

Figure Lengend Snippet: Effect of implanted fillers on the recruitment of PSCs and ingrowth of blood vessels following implantation in the periosteum of rat skull for a duration of 1 month. Scale bars, 100 μm. A Representative immunostainings of LepR+ PSCs, Emcn+ vessels, and OPN+ mature osteoblast in HA and PCL fillers. B , C Quantification of the relative Emcn+ vessel area in implants ( B ) and peri-implants ( C ). D Quantification of the relative LepR+ area in implants. Data are means ± SD. * P < 0.05, and *** P < 0.005 (unpaired two-tailed Student’s t test)

Article Snippet: Mouse Leptin Receptor (LepR) biotinylated antibody (BAF497) was sourced from R&D systems (Minneapolis, MN, USA).

Techniques: Two Tailed Test